Figure 2

Hydrogel-Based Formulations for Drug Delivery to the Posterior Segment of the Eye

AmirHossein Bahmanpour, Maryam Mollazadeh-Bajestani, Maryam Ghaff ari, Fathollah Moztarzadeh and Azadeh Sepahvandi*

Published: 12 September, 2023 | Volume 7 - Issue 1 | Pages: 038-050

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Figure 2:

Figure 2: Schematic of how bimatoprost-loaded polymer-nanoparticle (PNP) hydrogels are prepared and used to release drugs for a longer period in the vitreous humor (VH) through intravitreal (ITV) injection. A) A mixture of poly(ethylene glycol)-block-poly (lactic acid) nanoparticles (PEG-PLA NPs), HPMC-C12, and bimatoprost is created. Once injected, the hydrogels form a sustained delivery depot that releases bimatoprost gradually over an extended period. B) As time passes, the hydrogel gradually dissolves, releasing the drug and hydrogel components until there is no longer any depot material left. The drug is represented in the schematic by orange hexagons. C)The histopathological examination of rabbit eyes after the administration of PNP hydrogels showed a minimal to mild foreign body response (FBR) in the VH and along the ventral retina. Microscopic observations indicated that the PNP hydrogel caused some impact. An image of the full rabbit eye stained with hematoxylin and eosin (H&E) showed an affected region extending from the ciliary body and along the ventral peripheral retina, with a scale bar of 2500 µm. A closer look at the affected regions revealed the presence of foamy macrophages. Adapted and modified from [46].

Read Full Article HTML DOI: 10.29328/journal.abse.1001024 Cite this Article Read Full Article PDF

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