Relationship between Vitamin D Deficiency and Lipopolysaccharides Porphyromonas gingivalis Bacteria in Stunting Children
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Abstract
Background: Stunting is a condition of growth and development disorders in children under 5 years of age who appear shorter than their age caused by nutritional deficiencies. The stunted growth and development of children can be influenced by deficiencies in the intake of macronutrients such as protein and micronutrients such as calcium, phosphorus, zinc, and vitamin D. One nutrient that is relevant to current dental health research is vitamin D.
Objective: This review article will further analyze the relationship between vitamin D deficiency and Porphyromonas gingivalis bacterial lipopolysaccharide in stunting children.
Literature review: Vitamin D deficiency can cause various problems related to the oral cavity such as a decrease in salivary flow rate, buffer capacity, and salivary content such as protein. A decrease in salivary flow rate causes secretory Immunoglobulin A (IgA) to decrease, thus disrupting the colonization of normal microflora in the oral cavity. Reduced vitamin D levels can potentially increase the number of Porpyhromonas gingivalis bacteria and also lipopolysaccharides (LPS), thus inhibiting the proliferation and differentiation of alveolar bone cells.
Conclusion: Therefore, lack of micronutrient intake such as vitamin D deficiency can trigger the growth of Porphyromonas gingivalis bacteria and an increase in bacterial products such as lipopolysaccharides, especially in stunted children.
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Kesuma ZM, Siregar LR, Fradinata E, Fathimah A. Factors affecting stunting in children under 5 years of age in Indonesia using spatial model. Indian J Public Health. 2022;66(3):264. Available from: https://doi.org/10.4103/ijph.ijph_1989_21
Minervini G, Franco R, Marrapodi MM, Blasio MD, Ronsivalle V, Cicciu M. Children oral health and parents education status: a cross-sectional study. BMC Oral Health. 2023;23(787):2-7. Available from: https://doi.org/10.1186/s12903-023-03424-x
Reis CLB, Barbosa MCF, Henklein S, Madalena IR, Lima DC, Oliveira MA, et al. Nutritional status is associated with permanent tooth eruption in a group of Brazilian school children. Glob Pediatr Health. 2021;8:1-6. Available from: https://doi.org/10.1177/2333794X211034088
Kustanto A. The prevalence of stunting, poverty, and economic growth in Indonesia: a dynamic panel data causality analysis. J Develop Econ. 2021;6(2):150173. Available from: https://doi.org/10.20473/jde.v6i2.22358
Heo JS, Ahn YM, Kim AE, Shin SM. Breastfeeding and vitamin D. Clin Exp Pediatr. 2022;65:418–29. Available from: https://doi.org/10.3345/cep.2021.00444
Trave TD, Victoriano FG. Pregnancy, breastfeeding, and vitamin D. Int J Mol Sci. 2023;24(11881):2. Available from: https://doi.org/10.3390/ijms241511881
Cicek H, Duyuran R, Sri RMM, Ravichandran S. Biochemistry and metabolism of vitamin D. Int J Clin Biochem Res. 2023;10(1):28-36. Available from: https://doi.org/10.18231/j.ijcbr.2023.005
Alhelfi NM, Hoobi NM. Effect of vitamin D deficiency on dental caries and salivary parameters. J Med Chem Sci. 2023;6(6):1363. Available from: https://doi.org/10.26655/JMCHEMSCI.2023.6.16
Babina K, Salikhova D, Polyakova M, Svitich O, Samoylikov R, El-Abed SA, et al. The effect of oral probiotics (Streptococcus salivarius K12) on the salivary level of secretory immunoglobulin A, salivation rate, and oral biofilm: a pilot randomized clinical trial. Nutrients. 2022;14(1124):1-13. Available from: https://doi.org/10.3390/nu14051124
Almahmoud E, Alkazemi DUZ, Al-Qabandi W. Growth stunting and nutritional deficiencies among children and adolescents with celiac disease in Kuwait: a case-control study. Children. 2024;11(1042):1-17. Available from: https://doi.org/10.3390/children11091042
Suryani D, Kusdalinah, Pratiwi BA, Yandrizal. Differences in macronutrient and micronutrient intake of stunted toddlers in rural and urban areas of Bengkulu Province. Nat Nutr J. 2024;19(ISP):68-75. Available from: https://orcid.org/0000-0003-0056-8328
Martias I, Daswito R, Mukodri DML. Does water, hygiene, and sanitation indeed directly affect children’s stunting?: a scoping review. Int J Soc Sci. 2024;4(4):341-354. Available from: https://doi.org/10.53625/ijss.v4i4.8894
Nazri NS, Vanoh D, Leng SK. Malnutrition, low diet quality and its risk factors among older adults with low socioeconomic status: a scoping review. Nutr Res Rev. 2021;34:107. Available from: https://doi.org/10.1017/s0954422420000189
Chen S, Richardson S, Kong Y, Ma N, Zhao A, Song Y, et al. Association between parental education and simultaneous malnutrition among parents and children in 45 low-and middle-income countries. JAMA Netw Open. 2023;6(1):2. Available from: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800722#google_vignette
Theodorea CF, Diven S, Hendrawan D, Djais AA, Bachtiar BM, Widyarman AS, Seneviratne CJ. Characterization of oral Veillonella species in dental biofilms in healthy and stunted groups of children aged 6–7 years in East Nusa Tenggara. Int J Environ Res Public Health. 2022;19(13998):1-9. Available from: https://doi.org/10.3390/ijerph192113998
Hernández P, Sánchez MC, Llama-Palacios A, Ciudad MJ, Collado L. Strategies to combat caries by maintaining the integrity of biofilm and homeostasis during the rapid phase of supragingival plaque formation. Antibiotics. 2022;11:880. Available from: https://doi.org/10.3390/antibiotics11070880
Thomas C, Minty M, Vinel A, Canceill T, Loubières P, Burcelin R, et al. Oral microbiota: A major player in the diagnosis of systemic diseases. Diagnostics. 2021;11:1376. Available from: https://doi.org/10.3390/diagnostics11081376
Deo PN, Deshmukh RS. Oral microbiome research – a beginner’s glossary. J Oral Maxillofac Pathol. 2022;26(1):87. Available from: https://doi.org/10.4103/jomfp.jomfp_455_21
Wang J, Feng J, Zhu Y, Li D, Wang J, Chi W. Diversity and biogeography of human oral saliva microbial communities revealed by the Earth Microbiome Project. Front Microbiol. 2022;13. Available from: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.931065/full
Rajasekaran JJ, Krishnamurthy HK, Bosco J, Jayaraman V, Krishna K, Wang T, et al. Oral microbiome: A review of its impact on oral and systemic health. Microorganisms. 2024;12(1797):5-7. Available from: https://doi.org/10.3390/microorganisms12091797
Arweiler NB, Rahmel V, Alashkar Alhamwe B, Alhamdan F, Zemlin M, Boutin S, et al. Dental biofilm and saliva microbiome and its interplay with pediatric allergies. Microorganisms. 2021;9(6). Available from: https://doi.org/10.3390/microorganisms9061330
D’Agostino S, Ferrara E, Valentini G, Stoica SA, Dolci M. Exploring oral microbiome in healthy infants and children: A systematic review. Int J Environ Res Public Health. 2022;19:11403. Available from: https://doi.org/10.3390/ijerph191811403
Aleksijevic LH, Aleksijevic M, Skrlec I, Sram M, Sram M, Talapko J. Porphyromonas gingivalis virulence factors and clinical significance in periodontal disease and coronary artery diseases. Pathogens. 2022;11(1173):1-19. Available from: https://doi.org/10.3390/pathogens11101173
Kugaji M, Muddapur U, Bhat K, Joshi V, Manubolu M, Pathakoti K, Peram MR, Kumbar V. Variation in the occurrence of fimA genotypes of Porphyromonas gingivalis in periodontal health and disease. Int J Environ Res Public Health. 2020;17:1-2. Available from: https://www.mdpi.com/1660-4601/17/6/1826
Zhang Z, Liu D, Liu S, Zhang S, Pan Y. The role of Porphyromonas gingivalis outer membrane vesicles in periodontal disease and related systemic diseases. Front Cell Infect Microbiol. 2021;10(585917):1-12. Available from: https://doi.org/10.3389/fcimb.2020.585917
Fakhira FS, Garna H, Hadiati DE. Pengaruh defisiensi vitamin D terhadap proses pertumbuhan tulang pada balita stunting. Med Sci. 2023;3(1):860-62. Available from: https://doi.org/10.29313/bcsms.v3i1.6751
Rosli NFH, Nor NSM, Adnan RA, Kadir SHSA. A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine-related disorders. Clin Exp Pediatr. 2024;1-91. Available from: https://doi.org/10.3345/cep.2024.00227
Picolo M, Stephen A, Baysan A. The antimicrobial effect of different vitamin D compounds on Streptococcus mutans and their impact on glycosyltransferase expression. J Oral Microbiol. 2024;16:1-12. Available from: https://doi.org/10.1080/20002297.2024.2327758
Ji L, Gao J, Kong R, Gao Y, Ji X, Zhao D. Autophagy exerts pivotal roles in regulatory effects of 1α,25-(OH)₂D₃ on osteoclastogenesis. Biochem Biophys Res Commun. 2019;511:869-74. Available from: https://doi.org/10.1016/j.bbrc.2019.02.114
Cao W, Li J, Yang K, Cao D. An overview of autophagy: mechanism, regulation, and research progress. Bull Cancer. 2021;108:304-322. Available from: https://doi.org/10.1016/j.bulcan.2020.11.004
Dubey P, Mittal N. Periodontal diseases-a brief review. Int J Oral Health Dent. 2020;6(3):177-87. Available from: https://doi.org/10.18231/j.ijohd.2020.038
Meza-Meza MR, Ruiz-Ballesteros AI, de la Cruz-Mosso U. Functional effects of vitamin D: From nutrient to immunomodulator. Crit Rev Food Sci Nutr. 2022;62(11):3042-3062. Available from: https://doi.org/10.1080/10408398.2020.1862753
Salsabila N, Kasuma N, Yerizel E. Determinasi jumlah bakteri Porphyromonas gingivalis ATCC 33277 pada saliva anak stunting. e-GiGi. 2024;12(1):27. Available from: http://dx.doi.org/10.35790/eg.v12i1.47864
Marchetti E, Pizzolante T, Americo LM, Bizzaro S, Quinzi V, Mummolo S. Periodontology Part 4: Periodontal disease in children and adolescents. Eur J Paediatr Dent. 2022;23(4):332. Available from: http://dx.doi.org/10.23804/ejpd.2022.23.04.14
Lu EMC. The role of vitamin D in periodontal health and disease. J Periodontol Res. 2023;58:213-24. Available from: https://doi.org/10.1111/jre.13083
Meghil MM, Cutler CW. Influence of vitamin D on periodontal inflammation: a review. Pathogens. 2023;12(1180):6-8. Available from: https://doi.org/10.3390/pathogens12091180
Yang X, Niu L, Pan Y, Feng X, Liu J, Guo Y, Pan C, Geng F, Tang X. LL-37-induced autophagy contributed to the elimination of live Porphyromonas gingivalis internalized in keratinocytes. Front Cell Infect Microbiol. 2020;10:561761. Available from: https://doi.org/10.3389/fcimb.2020.561761